Obesity and cognition.

brain cognition

-Marina Muñoz Cervera-

This article published on 21 August 2012 in the journal Neurology brings us new knowledge about obesity and the cognitive function: Obesity phenotypes in midlife and cognition in early old age
The Whitehall II cohort study

The objetive was to examine the association of body mass index (BMI) and metabolic status with cognitive function and decline.

Methods: A total of 6,401 adults (71.2% men), aged 39–63 years in 1991–1993, provided data on BMI (normal weight 18.5–24.9 kg/m2, overweight 25–29.9 kg/m2; and obese ≥30 kg/m2) and metabolic status (abnormality defined as 2 or more of 1) triglycerides ≥1.69 mmol/L or lipid-lowering drugs, 2) systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥85 mm Hg, or antihypertensive drugs, 3) glucose ≥5.6 mmol/L or medications for diabetes, and 4) high-density lipoprotein cholesterol <1.04 mmol/L for men and <1.29 mmol/L for women). Four cognitive tests (memory, reasoning, semantic, and phonemic fluency) were administered in 1997–1999, 2002–2004, and 2007–2009, standardized to z scores, and averaged to yield a global score.

They obtained the following results:

Of the participants, 31.0% had metabolic abnormalities, 52.7% were normal weight, 38.2% were overweight, and 9.1% were obese. Among the obese, the global cognitive score at baseline (p = 0.82) and decline (p = 0.19) over 10 years was similar in the metabolically normal and abnormal groups. In the metabolically normal group, the 10-year decline in the global cognitive score was similar (p for trend = 0.36) in the normal weight (−0.40; 95% confidence interval [CI] −0.42 to −0.38), overweight (−0.42; 95% CI −0.45 to −0.39), and obese (−0.42; 95% CI −0.50 to −0.34) groups. However, in the metabolically abnormal group, the decline on the global score was faster among obese (−0.49; 95% CI −0.55 to −0.42) than among normal weight individuals (−0.42; 95% CI −0.50 to −0.34), (p = 0.03).

Conclusions: “In these analyses the fastest cognitive decline was observed in those with both obesity and metabolic abnormality”.

Link related:Obesity and metabolic syndrome

Source:

Archana Singh-Manoux, PhD, Sébastien Czernichow, MD, PhD, Alexis Elbaz, MD, PhD, Aline Dugravot, MSc, Séverine Sabia, PhD, Gareth Hagger-Johnson, PhD, Sara Kaffashian, MSc, Marie Zins, MD, PhD, Eric J. Brunner, PhD, Hermann Nabi, PhD and Mika Kivimäki, PhD

Neurology August 21, 2012 vol. 79 no. 8 755-762

http://www.neurology.org/content/79/8/755

Image: http://1.bp.blogspot.com/_wXOhLt8TORw/SwQkePemZkI/AAAAAAAAAJ8/C8CPfQeKZxU/s1600/when.jpeg

4 Respuestas a “Obesity and cognition.

  1. Hi there, I discovered your blog via Google whilst looking for a comparable matter, your website came up, it seems to be great. I’ve added to my favourites|added to my bookmarks.

    Me gusta

  2. I do trust all of the ideas you’ve introduced in your post. They’re really convincing and can certainly work. Nonetheless, the posts are very short for newbies. May just you please extend them a little from next time? Thanks for the post.

    Me gusta

Responder

Introduce tus datos o haz clic en un icono para iniciar sesión:

Logo de WordPress.com

Estás comentando usando tu cuenta de WordPress.com. Salir /  Cambiar )

Google photo

Estás comentando usando tu cuenta de Google. Salir /  Cambiar )

Imagen de Twitter

Estás comentando usando tu cuenta de Twitter. Salir /  Cambiar )

Foto de Facebook

Estás comentando usando tu cuenta de Facebook. Salir /  Cambiar )

Conectando a %s